New Research found that a special type of sugar named Trehalose reducing a risk of type 2 diabetes for mice when they feed that special type of sugar to mice.
According to the new research in mice, Trehalose the special type of sugar which blocks glucose from the liver and activates the gene that boosts insulin sensitivity, which totally reduces the chance of developing the risk of diabetes.
Activating the gene [Aloxe3] also triggers an increase in burning calories, results in reducing cholesterols, fat accumulation and weight gain.
The Results of this new study opens new possibilities for treating metabolic syndromes, a cluster related conditions like obesity, fatty liver diseases, and diabetes.
Research feed the Trehalose the special type of sugar via drinking water to the mice, resulted in beneficial effects in animal metabolisms. “Similar to the benefits that resulted from fasting”
While Fasting also this same mechanisms only happens, the liver turns on the same gene to improve the body’s ability to use insulin.
“We learned that this gene, Aloxe3, improves insulin sensitivity in the same way that common diabetes drugs – called thiazolidinediones –improve insulin sensitivity,” says Brian DeBosch, an assistant professor of pediatrics at Washington University in St. Louis.
“And we showed that Aloxe3 activation in the liver is triggered by both trehalose and by fasting, possibly for the same reason: depriving the liver of glucose.”
“In mice, this gene is turned on as part of what seems to be the normal fasting response. Our data suggest that fasting – or giving trehalose with a normal diet – triggers the liver to change the way it processes nutrients, in a beneficial way. And if glucose can be blocked from the liver with a drug, it may be possible to reap the benefits of fasting without strictly limiting food.”
Researchers also found that Aloxe3 in the liver, whether Trehalose or fasting activate it leads mice not only make better use of insulin but also helps to burn calories which results in the reducing the fat accumulations, obesity, cholesterol.
They also found that mice is subjected to take an obesity-inducing diet, but they didn’t get any obesity and didn’t develop metabolic diseases when they take trehalose via drinking water.
- Healthy liver of a mouse fed when typical chow diet.
- You can see large fatty deposits strained red. Liver of a mouse fed with High Cholesterol diet for 12 Weeks.
- Liver of a mouse fed with High Cholesterol diet, in addition of Aloxe 3 Gene turned on. See that Red fatty deposits are small when Aloxe 3 gene is activated.
However, DeBosch says, trehalose may encounter enzymes in the digestive tract that break it apart, releasing its two glucose molecules, which would be counterproductive. The researchers investigated a similar sugar—lactotrehalose—they found has the same beneficial effects from triggering Aloxe3 but does not break apart as easily.
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Journal Reference: Washington University in St. Louis